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gaba a antagonist gabazine  (Tocris)


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    Tocris gaba a antagonist gabazine
    Gaba A Antagonist Gabazine, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1027 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gaba+a+antagonist+gabazine/GABA/bio_rxiv__64898__2026__04__20__719622-157-13-20
    Average 96 stars, based on 1027 article reviews
    gaba a antagonist gabazine - by Bioz Stars, 2026-10
    96/100 stars

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    other:

    Article Title: Multiple sites of extinction for a single learned response
    Article Snippet: Twenty minutes before the start of the extinction session, ACSF or the GABA A antagonist gabazine (20 μM; Tocris) was infused into the inferior olive at a rate of 0.1 μl/min (total volumes 7–8 μl).

    Article Title: Subtype‐specific effects of dopaminergic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex
    Article Snippet: The NMDA antagonist, D‐APV, the dopamine D2‐like receptor agonist, quinpirole, the GABA a antagonist, gabazine, and the dopamine D2‐like antagonist, sulpiride, were purchased from Tocris Biosciences (Bristol, UK).

    Article Title: tVTA controls dual dopaminergic inputs to the external Globus Pallidus
    Article Snippet: IPSCs were recorded in voltage-clamp mode and their GABAergic nature confirmed using the GABA A antagonist gabazine (SR95531; 5 μM, Tocris Bioscience).

    Blocking Assay:

    Article Title: Perisomatic GABAergic synapses of basket cells effectively control principal neuron activity in amygdala networks
    Article Snippet: .. To block GABAergic synaptic transmission locally at the perisomatic region of PNs we applied a GABA A antagonist gabazine (1 μM, Tocris Bioscience) with a standard patch pipette on the cell body of the PN by continuous pressure, during whole cell recording of a monosynaptically connected interneuron-PN pair as described above. .. The gabazine solution also contained 100 μM Alexa594 sodium salt (Invitrogen), therefore the size of the puffed area could be monitored visually with the excitation of the fluorophore with a monochromator (Till Photonics).

    Transmission Assay:

    Article Title: Perisomatic GABAergic synapses of basket cells effectively control principal neuron activity in amygdala networks
    Article Snippet: .. To block GABAergic synaptic transmission locally at the perisomatic region of PNs we applied a GABA A antagonist gabazine (1 μM, Tocris Bioscience) with a standard patch pipette on the cell body of the PN by continuous pressure, during whole cell recording of a monosynaptically connected interneuron-PN pair as described above. .. The gabazine solution also contained 100 μM Alexa594 sodium salt (Invitrogen), therefore the size of the puffed area could be monitored visually with the excitation of the fluorophore with a monochromator (Till Photonics).

    Transferring:

    Article Title: Perisomatic GABAergic synapses of basket cells effectively control principal neuron activity in amygdala networks
    Article Snippet: .. To block GABAergic synaptic transmission locally at the perisomatic region of PNs we applied a GABA A antagonist gabazine (1 μM, Tocris Bioscience) with a standard patch pipette on the cell body of the PN by continuous pressure, during whole cell recording of a monosynaptically connected interneuron-PN pair as described above. .. The gabazine solution also contained 100 μM Alexa594 sodium salt (Invitrogen), therefore the size of the puffed area could be monitored visually with the excitation of the fluorophore with a monochromator (Till Photonics).



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    A : Experimental design. B : Spontaneous IPSPs (arrowheads) were recorded from identified VS neurons in control condition (black) and after gabazine (+GBZ, blue) and subsequent strychnine (+GBZ+STRY, purple) addition to the perfusion bath. GABA immunolabeling (green) could be observed in a small part of retrogradely marked VC neurons (red). Three consecutive episodes are illustrated for each condition. Insets illustrate IPSP doublets (scalebars: 1 mV, 10 ms). C-D : Occurrence (C) and parameters (D) of IPSPs in control (black) and after gabazine (blue) and subsequent strychnine (purple) perfusion. E-F : Same arrangement as C-D but with strychnine perfused first (light purple) and gabazine added subsequently (light blue).

    Journal: bioRxiv

    Article Title: Deciphering the role of brainstem vestibular-related inhibitory networks in shaping postural reflexes in the Xenopus tadpole

    doi: 10.1101/2025.11.16.688675

    Figure Lengend Snippet: A : Experimental design. B : Spontaneous IPSPs (arrowheads) were recorded from identified VS neurons in control condition (black) and after gabazine (+GBZ, blue) and subsequent strychnine (+GBZ+STRY, purple) addition to the perfusion bath. GABA immunolabeling (green) could be observed in a small part of retrogradely marked VC neurons (red). Three consecutive episodes are illustrated for each condition. Insets illustrate IPSP doublets (scalebars: 1 mV, 10 ms). C-D : Occurrence (C) and parameters (D) of IPSPs in control (black) and after gabazine (blue) and subsequent strychnine (purple) perfusion. E-F : Same arrangement as C-D but with strychnine perfused first (light purple) and gabazine added subsequently (light blue).

    Article Snippet: The fast GABAergic neurotransmission was blocked using the GABA-A receptor antagonist gabazine (1 μM; Merck), which was previously dissolved in distilled water in 1-ml aliquots stored at -20°C.

    Techniques: Control, Immunolabeling

    A-C : Gabazine effects. A: Control spinal reflex response evoked by sinewave stimulation of horizontal canal cupula on both sides. B: Reflex evoked under gabazine perfusion. C: Circular distribution (C1) of spinal burst peaks and mean discharge rate (C2; arbitrary units) in control (black) and under gabazine (blue). Note the appearance of a secondary little peak during the non-preferred phase of the GVS (* p<0.05). D-F : Strychnine effects. Same arrangement as A-C. Note the loss of coherence in the phase distribution (F1) and the spreading of the ‘peak’ response (F2) under strychnine.

    Journal: bioRxiv

    Article Title: Deciphering the role of brainstem vestibular-related inhibitory networks in shaping postural reflexes in the Xenopus tadpole

    doi: 10.1101/2025.11.16.688675

    Figure Lengend Snippet: A-C : Gabazine effects. A: Control spinal reflex response evoked by sinewave stimulation of horizontal canal cupula on both sides. B: Reflex evoked under gabazine perfusion. C: Circular distribution (C1) of spinal burst peaks and mean discharge rate (C2; arbitrary units) in control (black) and under gabazine (blue). Note the appearance of a secondary little peak during the non-preferred phase of the GVS (* p<0.05). D-F : Strychnine effects. Same arrangement as A-C. Note the loss of coherence in the phase distribution (F1) and the spreading of the ‘peak’ response (F2) under strychnine.

    Article Snippet: The fast GABAergic neurotransmission was blocked using the GABA-A receptor antagonist gabazine (1 μM; Merck), which was previously dissolved in distilled water in 1-ml aliquots stored at -20°C.

    Techniques: Control

    A-C : Gabazine effects. A: GVS-evoked spinal response throughout the 10-cycle repeated stimulation in control (black and under gabazine perfusion (blue). Both the raw traces (bottom) and the integrated signals (top) are illustrated. B: Evolution of the response magnitude (measured as the mean area under the integrated curve). C: First (C1) and last (C2) mean areas in control (black) and under gabazine (blue). Note the distinct effects between the first and later GVS cycles (** p>0.01; * p<0.05). D-F : Strychnine effects. Same arrangement as A-C.

    Journal: bioRxiv

    Article Title: Deciphering the role of brainstem vestibular-related inhibitory networks in shaping postural reflexes in the Xenopus tadpole

    doi: 10.1101/2025.11.16.688675

    Figure Lengend Snippet: A-C : Gabazine effects. A: GVS-evoked spinal response throughout the 10-cycle repeated stimulation in control (black and under gabazine perfusion (blue). Both the raw traces (bottom) and the integrated signals (top) are illustrated. B: Evolution of the response magnitude (measured as the mean area under the integrated curve). C: First (C1) and last (C2) mean areas in control (black) and under gabazine (blue). Note the distinct effects between the first and later GVS cycles (** p>0.01; * p<0.05). D-F : Strychnine effects. Same arrangement as A-C.

    Article Snippet: The fast GABAergic neurotransmission was blocked using the GABA-A receptor antagonist gabazine (1 μM; Merck), which was previously dissolved in distilled water in 1-ml aliquots stored at -20°C.

    Techniques: Control

    A-H : Gabazine effects on spinal responses evoked by LVST (A-D) or TAN (E-H) direct stimulation. A: Experimental design for LVST. B: Samples of spinal fast responses in control (black) and under gabazine (blue). Arrowhead point to the response onset. C: Mean occurrence of spinal fast responses over 5 repeated stimulations (* p<0.05). D: Mean areas under the integrated curve of the response (* p<0.05). E-H: Same arrangement as A-D, for TAN stimulation. I-R : Strychnine effects. Same arrangement as A-H.

    Journal: bioRxiv

    Article Title: Deciphering the role of brainstem vestibular-related inhibitory networks in shaping postural reflexes in the Xenopus tadpole

    doi: 10.1101/2025.11.16.688675

    Figure Lengend Snippet: A-H : Gabazine effects on spinal responses evoked by LVST (A-D) or TAN (E-H) direct stimulation. A: Experimental design for LVST. B: Samples of spinal fast responses in control (black) and under gabazine (blue). Arrowhead point to the response onset. C: Mean occurrence of spinal fast responses over 5 repeated stimulations (* p<0.05). D: Mean areas under the integrated curve of the response (* p<0.05). E-H: Same arrangement as A-D, for TAN stimulation. I-R : Strychnine effects. Same arrangement as A-H.

    Article Snippet: The fast GABAergic neurotransmission was blocked using the GABA-A receptor antagonist gabazine (1 μM; Merck), which was previously dissolved in distilled water in 1-ml aliquots stored at -20°C.

    Techniques: Control

    A-D : LVST-evoked responses. A: Experimental design. B: Sample spinal responses to cut-sensitive (bottom) and insensitive (top) stimulation sites in the LVST, in control (black), and after commissural cut (light green) and subsequent gabazine perfusion (dark green). Arrowheads point to response onsets. C: Mean response occurrence over 5 consecutive stimulations. D: Mean response magnitude (measured as the mean area under the response integrated curve; * p<0.05) in preparations affected by the commissural cut (doted box in C). E-H : Same arrangement as A-D, for TAN stimulation.

    Journal: bioRxiv

    Article Title: Deciphering the role of brainstem vestibular-related inhibitory networks in shaping postural reflexes in the Xenopus tadpole

    doi: 10.1101/2025.11.16.688675

    Figure Lengend Snippet: A-D : LVST-evoked responses. A: Experimental design. B: Sample spinal responses to cut-sensitive (bottom) and insensitive (top) stimulation sites in the LVST, in control (black), and after commissural cut (light green) and subsequent gabazine perfusion (dark green). Arrowheads point to response onsets. C: Mean response occurrence over 5 consecutive stimulations. D: Mean response magnitude (measured as the mean area under the response integrated curve; * p<0.05) in preparations affected by the commissural cut (doted box in C). E-H : Same arrangement as A-D, for TAN stimulation.

    Article Snippet: The fast GABAergic neurotransmission was blocked using the GABA-A receptor antagonist gabazine (1 μM; Merck), which was previously dissolved in distilled water in 1-ml aliquots stored at -20°C.

    Techniques: Control